LAK cells are derived from lymphocytes incubated with which cytokine?

Prepare for the AAB Medical Technologist (MT) Generalist Exam with flashcards and multiple choice questions. Each question includes hints and explanations to boost your understanding. Get exam-ready now!

LAK cells, or Lymphokine-Activated Killer cells, are a type of immune cell that can effectively kill tumor cells. They are derived from peripheral blood lymphocytes that have been incubated with interleukin-2 (IL-2). IL-2 is a cytokine that plays a vital role in the growth, proliferation, and activation of T cells, especially in the context of immune responses. When lymphocytes are exposed to IL-2, they undergo activation and transformation into LAK cells, enhancing their cytotoxic capabilities against cancerous cells.

Interferon-gamma, tumor necrosis factor, and interleukin-6, while important in various immune functions, do not directly promote the formation of LAK cells from lymphocytes in the same way IL-2 does. Interferon-gamma primarily enhances immune responses and has antiviral effects, tumor necrosis factor is involved in inflammation and apoptosis, and interleukin-6 is associated with inflammation and immune responses but does not play a direct role in generating LAK cells. Hence, interleukin-2 is the key cytokine necessary for the activation and transformation of lymphocytes into LAK cells.

Subscribe

Get the latest from Examzify

You can unsubscribe at any time. Read our privacy policy