Of the Duffy antigen system, which antibody is known to potentially cause transfusion reactions?

Prepare for the AAB Medical Technologist (MT) Generalist Exam with flashcards and multiple choice questions. Each question includes hints and explanations to boost your understanding. Get exam-ready now!

The Duffy antigen system is significant in transfusion medicine due to the antibodies associated with it. Among the antibodies listed, Anti-Fya is known for its potential to cause transfusion reactions. This antibody can elicit an immune response when transfused into someone who is Fya negative, leading to hemolytic transfusion reactions.

Anti-Fya targets the Fya antigen on red blood cells, and when a recipient does not have this specific antigen and receives blood containing Fya positive red blood cells, their immune system may recognize these as foreign and mount a response. Consequently, this can result in hemolysis of the transfused cells, presenting clinical complications.

While other antibodies such as Anti-Jka and Anti-Fyb are also part of the Duffy system and can cause transfusion reactions, Anti-Fya is particularly noted for its clinical implication in transfusion practices. Understanding the potential for certain antibodies, like Anti-Fya, to induce adverse reactions is crucial for ensuring safe blood transfusion practices and compatibility testing.

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