What is indicated by a positive direct antiglobulin test?

Prepare for the AAB Medical Technologist (MT) Generalist Exam with flashcards and multiple choice questions. Each question includes hints and explanations to boost your understanding. Get exam-ready now!

A positive direct antiglobulin test (DAT) indicates the presence of antibodies or complement proteins attached to the surface of red blood cells. This test is primarily used to diagnose conditions where the immune system erroneously targets and destroys red blood cells, such as autoimmune hemolytic anemia. In this condition, the body produces antibodies against its own red blood cells, leading to their destruction, which can result in anemia and other related symptoms.

Normal immune responses and stable hemoglobin levels do not typically result in a positive DAT, since these conditions do not involve the inappropriate binding of antibodies to red blood cells. Additionally, uncomplicated transfusions would not lead to a positive DAT unless there were underlying immune reactions, indicating that the body's immune system is responding to the transfused red blood cells, which would not be considered uncomplicated. Thus, a positive DAT is strongly associated with autoimmune hemolytic anemia, making it the correct answer.

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