What is the correct order of antibody classes from most common to least common?

Prepare for the AAB Medical Technologist (MT) Generalist Exam with flashcards and multiple choice questions. Each question includes hints and explanations to boost your understanding. Get exam-ready now!

The correct order of antibody classes from most common to least common is IgG, IgA, IgM, IgD, and IgE. IgG is the most prevalent antibody in the bloodstream, accounting for about 75-80% of the antibodies present, making it crucial for immune defense against pathogens. It has a long half-life, which allows it to provide prolonged immunity, especially after vaccination or previous infections.

IgA, comprising about 10-15% of the total antibody pool, is primarily found in mucosal areas, such as the gut, respiratory tract, and urogenital tract, as well as in secretions like saliva and breast milk. Its role is to protect mucosal surfaces from infection.

IgM is the first antibody produced in response to an infection and accounts for about 5-10% of the antibodies. It is effective in forming complexes with antigens and activating the complement system to enhance the immune response.

IgD is found in very small amounts (around 0.2% of total antibodies) and is primarily located on the surface of B cells as a receptor rather than in circulation. Its exact function is not entirely understood, but it is thought to play a role in B cell activation.

IgE

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