What is the most common antibody detected in blood banking, aside from ABO and Rh antibodies?

The most common antibody detected in blood banking aside from ABO and Rh antibodies is Anti-K. The Anti-K antibody is significant because it can make blood transfusions more complex; individuals who have the K antigen (Kell system) can develop this antibody if they are exposed to K-positive blood. It is notable for its potential to cause hemolytic disease of the fetus and newborn (HDFN) and for its association with hemolytic transfusion reactions.

In blood banking practices, the detection and identification of antibodies such as Anti-K are crucial for ensuring compatibility in blood transfusions. The Kell blood group system is one of the most clinically significant blood group systems recognized, making Anti-K a key focus for technologists in the laboratory setting.

The other antibodies mentioned, while important, do not have the same frequency of detection as Anti-K. Anti-Jka, Anti-Lea, and Anti-Duffy are also significant but occur less commonly in the population. Their presence can lead to alloimmunization, but they do not reach the clinical significance and prevalence of Anti-K in everyday blood banking.