Which condition is most consistent with high iron levels, high ferritin, and normal total iron binding capacity?

The condition that is most consistent with high iron levels, high ferritin, and normal total iron binding capacity is hemochromatosis. In hemochromatosis, there is excessive absorption of iron from the diet, leading to high levels of iron in the body. Alongside this, ferritin, which is a protein that stores iron in the body, is elevated due to the high iron load.

Total iron binding capacity (TIBC) measures the blood's capacity to bind iron with transferrin, which is a protein that transports iron. In hemochromatosis, because the body stores excessive iron, there is often a decreased amount of transferrin in circulation, which results in a normal or low TIBC. The combination of high iron, high ferritin, and normal TIBC is characteristic of hemochromatosis.

Other conditions like iron deficiency anemia present low iron levels, low ferritin, and high TIBC as the body attempts to maximize iron transport and absorption. Sideroblastic anemia often shows increased iron levels with ineffective erythropoiesis but usually does not have normal TIBC. Thalassemia may present with normal or low ferritin levels depending on the subtype and stage of the disease.