Which type of red blood cell is characterized by a target shape in a blood smear?

Target cells, also known as codocytes, are characterized by their distinctive target appearance in a blood smear. This morphology typically presents as a central area of hemoglobin surrounded by a ring of clear space, which creates the target-like outline. This shape can be indicative of several underlying conditions, including liver disease, hemoglobinopathies, and certain types of anemia. The altered lipid membrane composition and reduced volume of these cells contribute to their unique form and signify changes in the cellular environment or metabolism.

Recognizing target cells is essential for laboratory professionals, as it aids in diagnosing and understanding the broader context of patient health, leading to appropriate further investigations or management for the associated condition. This is why understanding the morphology of red blood cells, such as target cells, is a key aspect of hematology within the medical technologist's scope of practice.